Methadone hydrochloride tablets are an opioid agonist shown for the management of moderate to extreme pain when a persistent, around-the-clock opioid pain-relieving is required for an extended period of time. detoxification treatment of opioid addiction (heroin or other morphine-like drugs). maintenance treatment of opioid compulsion (heroin or other morphine-like drugs), in conjunction with fitting social and therapeutic administrations.




Abuse Potential Methadone hydrochloride tablets contain methadone, an opioid agonist, and Plan II controlled substance with a mishandle obligation comparable to other opioid agonists, lawful or illicit. Assess each patient’s chance for opioid manhandle or habit earlier to endorsing methadone hydrochloride tablets.
The hazard for opioid manhandle is expanded in patients with an individual or family history of substance mishandle (counting sedate or alcohol mishandle or habit) or mental ailment (e.g., major depressive clutter).
Routinely screen all patients accepting methadone hydrochloride tablets for signs of abuse, manhandle, and compulsion amid treatment.
Life-Threatening Respiratory DepressionRespiratory misery, counting lethal cases, have been detailed amid start and transformation of patients to methadone hydrochloride tablets, and indeed when t


  • Methadone is contraindicated in patients with:
    • Significant respiratory depression.
    • Acute or severe bronchial asthma.
    • Known or suspected paralytic ileus.
    • Hypersensitivity to methadone.


Methadone isn’t demonstrated as an as-needed (PRN) analgesic, for pain that’s mellow or not anticipated to endure for an amplified period of time, for intense torment, or post-operative pain.
Respiratory depression, which happens more regularly in elderly or weakened patients, is the chief risk related to methadone hydrochloride organization.
Methadone’s crest respiratory depressant impacts regularly happen afterward, and endure longer than its crest pain-relieving impacts, especially amid the beginning dosing period.
Patients are tolerant to other opioids maybe not completely tolerant to methadone.
Deficient cross-tolerance is of specific concern for patients tolerant to other mu-opioid agonists who are being changed over to treatment with methadone, hence making assurance of dosing amid opioid treatment change complex. Methadone restrains cardiac potassium channels and drags out the QT interval.
Serious arrhythmia (torsades de pointes) has been watched amid treatment with methadone.
Maintain a strategic distance from concurrent utilize of CNS depressants (such as liquor) and methadone as this seems to increment the chance for respiratory discouragement, hypotension, and significant sedation.
Methadone, a mu-agonist opioid with a manhandle obligation comparable to other opioid agonists may be a Plan II controlled substance and like other opioids utilized in absence of pain, can be manhandled and are subject to criminal diversion.
Methadone ought to be utilized with caution in elderly and weakened patients; patients who are known to be touchy to central anxious framework depressants, such as those with cardiovascular, aspiratory, renal, or hepatic malady; and in patients with comorbid conditions or concomitant medicines which may incline to dysrhythmia.

Monitor patients with significant chronic obstructive pulmonary disease or cor pulmonale, and patients having a substantially diminished respiratory save, hypoxia, hypercapnia, or pre-existing respiratory misery for respiratory sadness, especially when starting treatment and titrating with methadone hydrochloride tablets, as in these patients, indeed regular helpful dosages of methadone hydrochloride tablets may diminish respiratory drive to the point of apnea.

Hypotension, significant sedation, coma, or respiratory sadness may result in the event that methadone hydrochloride tablets are utilized concomitantly with other CNS depressants (e.g., narcotics, anxiolytics, hypnotics, neuroleptics, other opioids).

Methadone hydrochloride tablets may cause extreme hypotension counting orthostatic hypotension and syncope in mobile patients. There’s an expanded hazard in patients whose capacity to preserve blood weight has as of now been compromised by a decreased blood volume or concurrent organization of certain CNS depressant drugs (e.g. phenothiazines or common anesthetics).
Methadone hydrochloride tablets may diminish respiratory drive, and the resultant CO2 maintenance can encourage increment intracranial weight.

Opioids may too darken the clinical course in an understanding with a head injury. Methadone hydrochloride tablets may cause a fit of the sphincter of Oddi.

Methadone may exasperate convulsions in patients with convulsive disorders and may actuate or aggravate seizures in a few clinical settings.
Use of fractional agonists or blended opioid agonists/antagonists analgesics may diminish the pain-relieving impact and/or may accelerate withdrawal indications.
Don’t suddenly suspend methadone hydrochloride tablets. Methadone may disable the mental or physical capacities required to perform possibly perilous exercises such as driving a car or working apparatus.

Shipping & Storage 

Storage Information
LIGHT SENSITIVE, AIR SENSITIVE: Keep tightly closed in light-resistant containers.

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